The health care industry’s transformational, irreversible changes make it clear that hospital-centric, disease-focused, acute episodes of care are not the future. This is creating confusion for caregivers on the front lines, who may no longer understand their roles or how to apply their knowledge. As board members, executives and physician leaders begin to rethink how and to whom care is delivered and how it is paid for, many are asking how to create high-performance organizations.